VIRUS-LIKE PARTICLES FOR TREATMENT OF VIRAL INFECTIONS

摘要

The invention provides virus-like particles for treatment of viral infections based on the virus causing the infection. The virus-like particles comprise the virus recombinant proteins that form a capsid, recombinant virus membrane proteins attached to the capsid and vRNA packaged within said capsid. The vRNA is generated from a DNA sequence encoding a polypeptide capable of specifically binding to a constant region of a nonstructural protein of the virus that is essential for propagation of the virus.

主权项

1. A virus-like particle adapted for treating a viral infection, wherein
said virus-like particle is based on an infecting virus causing the viral infection, with the proviso that said infecting virus is not a hepatitis C virus, and said virus-like particle comprises: recombinant viral proteins which are of the same species as said infecting virus and form a capsid, recombinant viral membrane proteins which are of the same species as said infecting virus and are attached to the surface of said capsid, and vRNA packaged within said capsid, wherein said vRNA is generated by intracellular transcription of a DNA sequence encoding a polypeptide capable of specifically binding to a constant region of a nonstructural protein of said infecting virus, said nonstructural protein being essential for propagation of said infecting virus, whereby said binding interferes with the activity of said nonstructural viral protein and inhibits the propagation of said virus.