METHODS FOR TREATING EYE DISORDERS USING OPIOID RECEPTOR ANTAGONISTS

摘要

The present invention discloses methods for treating eye disorders using opioid receptor antagonists. The methods include the step of administering an effective amount of a topically-administered opioid receptor antagonist in the absence of moxifloxacin. Preferably, the topically-administered opioid receptor antagonist is formulated as a solution. Preferably, the topically-administered opioid receptor antagonist is at least one agent selected from the group consisting of: naltrexone, naloxone, nalmefene, and a pharmaceutically-acceptable salt thereof. Preferably, the effective amount corresponds to a concentration of at least about 10−7 molarity. Preferably, the effective amount is based on a treatment administration of at least once every other day.

主权项

1. A method for treating anterior segment eye disorders using opioid receptor antagonists, the method comprising the step of:
(a) administering an effective amount of a topically-administered opioid receptor antagonist, in the absence of moxifloxacin, for treating eye disorders affecting the anterior segment of the eye, wherein said topically-administered opioid receptor antagonist is at least one agent selected from the group consisting of: naltrexone, naloxone, nalmefene, and a pharmaceutically-acceptable salt thereof.