| 摘要 |
The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I),;;wherein R1 is H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like. |
| 主权项 |
1. A compound of general formula (I): or a pharmacologically acceptable salt thereof, wherein R1 represents a hydrogen atom, a C1-C6 alkyl group, a hydroxy(C1-C6 alkyl) group, a (C1-C6 alkoxy)-(C1-C6 alkyl) group, a hydroxy(C1-C6 alkoxy)-(C1-C6 alkyl) group, a (C1-C6 alkyl)amino-(C1-C6 alkyl) group, a hydroxy(C1-C6 alkyl)amino-(C1-C6 alkyl) group, a [N—(C1-C6 alkyl)-N-hydroxy(C1-C6 alkyl)amino]-(C1-C6 alkyl) group, a (C1-C6 alkyl)sulfonylamino-(C1-C6 alkyl) group, a [N—(C1-C6 alkyl)-N—(C1-C6 alkyl)sulfonylamino]-(C1-C6 alkyl) group, a carboxy(C1-C6 alkyl) group, a halogeno(C1-C6 alkyl) group, a (C3-C8 cycloalkyl)-(C1-C6 alkyl) group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, a C3-C8 cycloalkyl group, a C3-C8 cycloalkenyl group, a hydroxy group, a C1-C6 alkoxy group, a hydroxy(C1-C6 alkoxy) group, a (C1-C6 alkoxy)-(C1-C6 alkoxy) group, a (C1-C6 alkyl)sulfonyl-(C1-C6 alkoxy) group, a carboxy(C1-C6 alkoxy) group, a halogeno(C1-C6 alkoxy) group, a C1-C6 alkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, an amino group, a C1-C6 alkylamino group, a di(C1-C6 alkyl)amino group, a hydroxy(C1-C6 alkyl)amino group, a N—(C1-C6 alkyl)-N-hydroxy(C1-C6 alkyl)amino group, a formylamino group, a (C1-C6 alkyl)carbonylamino group, a carboxy group, a (C1-C6 alkoxy)carbonyl group, a carbamoyl group, a (C1-C6 alkylamino)carbonyl group, a di(C1-C6 alkyl)aminocarbonyl group, a cyano group, a halogeno group, a phenyl group, a substituted phenyl group in which the substituent(s) represent 1 to 4 groups independently selected from Substituent Group α, a 5- or 6-membered aromatic heterocyclyl group, a substituted 5- or 6-membered aromatic heterocyclyl group in which the substituent(s) represent 1 to 4 groups independently selected from Substituent Group α, a 5- or 6-membered saturated heterocyclyl group, a substituted 5- or 6-membered saturated heterocyclyl group in which the substituent(s) represent 1 to 4 groups independently selected from Substituent Group α, a 5- or 6-membered saturated heterocyclyl-(C1-C6 alkyl) group, a substituted 5- or 6-membered saturated heterocyclyl-(C1-C6 alkyl) group in which the substituent(s) represent 1 to 4 groups independently selected from Substituent Group α, a 5- or 6-membered saturated heterocyclyloxy group, a substituted 5- or 6-membered saturated heterocyclyloxy group in which the substituent(s) represent 1 to 4 groups independently selected from Substituent Group α, a 5- or 6-membered saturated heterocyclylcarbonyl group or a substituted 5- or 6-membered saturated heterocyclylcarbonyl group in which the substituent(s) represent 1 to 4 groups independently selected from Substituent Group α, and Substituent Group α represents the group consisting of a C1-C6 alkyl group, a hydroxy(C1-C6 alkyl) group, a halogeno(C1-C6 alkyl) group, a (C3-C8 cycloalkyl)-(C1-C6 alkyl) group, a C3-C8 cycloalkyl group, a hydroxy group, a C1-C6 alkoxy group, a halogeno(C1-C6 alkoxy) group, a C1-C6 alkylamino group, a di(C1-C6 alkyl)amino group, a carboxy group, a (C1-C6 alkoxy)carbonyl group, a carbamoyl group, a (C1-C6 alkylamino)carbonyl group, a di(C1-C6 alkyl)aminocarbonyl group, a cyano group, a halogeno group and an oxo group. |
