| 发明名称 |
HUMANIZED ANTI-HMGB1 ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF |
| 摘要 |
The present invention provides: a humanized anti-HMGB1 antibody that binds specifically to a sequence consisting of an eight-amino-acid residue (EEEDDDDE) at the C terminal of the HMGB1 protein, and that is effective in the treatment or prophylaxis of various inflammatory diseases related to said protein; an antigen-binding fragment of said antibody; and a pharmaceutical composition including said antibody or said antigen-binding fragment thereof. |
| 申请公布号 |
WO2014115430(A1) |
申请公布日期 |
2014.07.31 |
| 申请号 |
WO2013JP82860 |
申请日期 |
2013.12.06 |
| 申请人 |
EVEC INC.;NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY |
发明人 |
TAKADA KENZO;TORASHIMA TAKASHI;NISHIBORI MASAHIRO |
| 分类号 |
C07K16/46;A61K39/395;A61P1/16;A61P9/10;A61P11/00;A61P13/12;A61P25/04;A61P25/28;A61P29/00;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09 |
主分类号 |
C07K16/46 |
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