主权项 |
1. A population of isolated peptides comprising three or more different peptides, wherein each peptide in the population comprises a sequence of:
(i) S-X2-K-E-X5-K-Q-X8-T-X10-X11-X12-X13-G-L-K-Q-X18-W-X20-G-X22-X23-X24-X25-X26-G-G-G-G-G-N-F-S-A-K-E-E-X39-A-E-T-R-X44-T-F-G-L-X49-K-Q-Y-D-G-A-X56-I-X58-E-N-Q-V-Q-N-K-F-T-I-S-N-C (SEQ ID NO: 72) or fragment thereof, wherein X2 is an amino acid selected from the group consisting of A and V, X5 is an amino acid selected from the group consisting of E and D, X8 is an amino acid selected from the group consisting of T and P, X10 is an amino acid selected from the group consisting of T and V, X11 is an amino acid selected from the group consisting of G and A, X12 is an amino acid selected from the group consisting of L and V, X13 is an amino acid selected from the group consisting of Y and F, X18 is an amino acid selected from the group consisting of D and N, X20 is an amino acid selected from the group consisting of D and N, X22 is an amino acid selected from the group consisting of S and V, X23 is an amino acid selected from the group consisting of A, S, and T, X24 is an amino acid selected from the group consisting of A and I, X25 is an amino acid selected from the group consisting of T and P, X26 is an amino acid selected from the group consisting of S, N, and K, X39 is any amino acid, X44 is any amino acid, X49 is any amino acid, X56 is any amino acid, and X58 is any amino acid, or (ii) S-X2-K-E-X5-K-Q-X8-T-X10-X11-X12-X13-G-L-K-Q-X18-W-X20-G-X22-X23-X24-X25-X26-G-G-G-G-G-N-F-S-A-K-E-E-X39-A-X41-T-R-X44-T-F-G-X48-X49-K-Q-Y-D-G-A-X56-I-X58-E-N-Q-V-Q-N-K-F-T-I-S-N-C (SEQ ID NO: 3) or a fragment thereof, wherein X2 is an amino acid selected from the group consisting of A and V, X5 is an amino acid selected from the group consisting of E and D, X8 is an amino acid selected from the group consisting of T and P, X10 is an amino acid selected from the group consisting of T and V, X11 is an amino acid selected from the group consisting of G and A, X12 is an amino acid selected from the group consisting of L and V, X13 is an amino acid selected from the group consisting of Y and F, X18 is an amino acid selected from the group consisting of D and N, X20 is an amino acid selected from the group consisting of D and N, X22 is an amino acid selected from the group consisting of S and V, X23 is an amino acid selected from the group consisting of A, S, and T, X24 is an amino acid selected from the group consisting of A and I, X25 is an amino acid selected from the group consisting of T and P, X26 is an amino acid selected from the group consisting of S, N, and K, X39 is any amino acid, X41 is an amino acid selected from the group consisting of D and N, X44 is any amino acid, X48 is an amino acid selected from the group consisting of V and A, X49 is any amino acid, X56 is any amino acid, and X58 is any amino acid. |