发明名称 |
ANTIVIRAL MACROCYCLES |
摘要 |
Cyclosporin derivatives, methods of manufacturing the cyclosporin derivatives and methods for treating subjects infected with certain viruses, including hepatitis virus or HIV by administering the cyclosporin derivatives are described. |
申请公布号 |
US2014213508(A1) |
申请公布日期 |
2014.07.31 |
申请号 |
US201314059308 |
申请日期 |
2013.10.21 |
申请人 |
Scynexis, Inc. |
发明人 |
Li Keqiang;PEEL Michael Robert |
分类号 |
C07K7/64;C07C317/14;C07C229/48;C07C271/24 |
主分类号 |
C07K7/64 |
代理机构 |
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代理人 |
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主权项 |
1. A cyclosporine A derivative in which the 3-Sarcosine position is substituted by a group —S—CH2C[CH2(CH2)n]NR2R3, wherein R2 is hydrogen or an alkyl chain having from one to four carbon atoms and, when the alkyl chain has 3 or 4 carbon atoms, the chain is a straight or branched; R3 is an alkyl chain having from one to four carbon atoms and, when the alkyl chain has 3 or 4 carbon atoms the chain is a straight or branched; and n is 1 or 2. |
地址 |
Durham NC US |