| 发明名称 |
COMPLEX SETS OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR COLON CANCER |
| 摘要 |
The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. |
| 申请公布号 |
US2014213476(A1) |
申请公布日期 |
2014.07.31 |
| 申请号 |
US201214239264 |
申请日期 |
2012.08.03 |
| 申请人 |
Keller Andreas;Beier Markus;Meese Eckart;Leidinger Petra;Wendschlag Anke |
发明人 |
Keller Andreas;Beier Markus;Meese Eckart;Leidinger Petra;Wendschlag Anke |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for diagnosing and/or prognosing of colon cancer comprising the steps of:
(i.) determining an expression profile of a set comprising at least two miRNAs representative for colon cancer in a blood sample from a subject, and (ii.) comparing said expression profile to a reference, wherein the comparison of said expression profile to said reference, allows for the diagnosis and/or prognosis of colon cancer, wherein the nucleotide sequences of the miRNAs comprised in the set are selected from the group consisting of SEQ ID NO: 1 to 588, a fragment thereof, and a sequence having at least 80% sequence identity thereto. |
| 地址 |
Püttlingen DE |
