发明名称 |
Substituted oxazolidinone derivatives and their use as factor xa inhibitors |
摘要 |
<p>N-oxazolidinylmethyl-substituted (benzo)thiophene carboxamides (I) and their salts, hydrates and prodrugs are new. N-oxazolidinylmethyl-substituted (benzo)thiophene carboxamides of formula (I) and their salts, hydrates and prodrugs are new. [Image] R 1> : optionally benzo-fused thiophene, optionally substituted one or more times; R 2> : any selected organic group; R 3>-R 8> : same or different hydrogen or 1-6C alkyl. Excluded are compounds where R 2> = phenyl (optionally substituted once or more) and all of R 3>-R 8> are hydrogen. Independent claims are also included for the following: (1) preparation of (I); and (2) pharmaceutical composition containing (I), optionally also auxiliaries and carriers. ACTIVITY : Anticoagulant; cardiant; anti-anginal; vasotropic; thrombolytic; cerebroprotective; antiarthritic; antiarteriosclerotic; cytostatic; nootropic; neuroprotective. Test details are described but no results given. MECHANISM OF ACTION : Coagulation factor Xa Inhibitor.</p> |
申请公布号 |
SI1526132(T1) |
申请公布日期 |
2014.07.31 |
申请号 |
SI20000031079T |
申请日期 |
2000.12.11 |
申请人 |
BAYER INTELLECTUAL PROPERTY GMBH |
发明人 |
STRAUB ALEXANDER DR.;LAMPE THOMAS DR.;POHLMANN JENS DR.;ROHRIG SUSANNE DR.;PERZBORN ELISABETH DR.;SCHLEMMER KARL-HEINZ DR.;PERNERSTORFER JOSEPH DR. |
分类号 |
A61K31/42;A61K31/422;A61K31/423;A61K31/424;A61K31/427;A61K31/428;A61K31/4365;A61K31/444;A61K31/454;A61K31/496;A61K31/5355;A61K31/5377;A61K31/538;A61K31/5383;A61K31/541;A61P7/00;A61P7/02;A61P9/10;A61P19/02;A61P25/28;A61P35/00;A61P43/00;C07D413/12;C07D413/14;C07D417/14;C07D495/04;C07D498/04 |
主分类号 |
A61K31/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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