METHODS OF INCREASING EPA BLOOD LEVELS

摘要

In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.

主权项

1. A method of increasing a concentration of EPA in plasma or RBCs of a subject having baseline fasting triglycerides of at least about 500 mg/dl, the method comprising administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of EPA per day, wherein upon administering the composition to the subject daily for a period of 12 weeks, the subject exhibits an increase in the concentration of EPA in plasma and/or RBCs of at least 100% compared to a control subject who is not administered EPA, wherein the control subject also has baseline fasting triglycerides of at least about 500 mg/dl.