T CELL RECEPTOR AND USES THEREOF

摘要

A method has been developed to efficiently proliferate and culture a CTL specific to WT1 peptides under limiting dilution conditions. Utilizing this method, CTLs capable of recognizing both a state where a wildtype WT1 specific peptide is presented by HLA-A*24:02 and a state where a mutant WT1 specific peptide is presented by HLA-A*24:02 have been successfully obtained.

主权项

1. An isolated T cell receptor complex comprising:
a T cell receptor α-chain protein having amino acid sequences of SEQ ID NOs: 1 to 3; and a T cell receptor β-chain protein having amino acid sequences of SEQ ID NOs: 5 to 7.