摘要 |
A compound of formula (I) in which the dotted lines indicate the presence of at least one double bond; n = 0 to 4; R3 and R4 are H, or when n = 1, R3 and R4 can also form together a double bond between the carbon atoms, and m = 0, 1 or 2, Z is CH or N or Z is C and - CHR3- is =CH- linked by the double bond to cyclopentanone; or - (-)m- is absent, and Z is NH, >N-alkyl, >N-phenyl, >N-benzyl or >N heteroaryl; R8 is alkyl, aryl or heteroaryl which can be optionally substituted; EWG represents an electron withdrawing group selected from the group comprising COOR, COSR, CONRR', CN, COR, CF3, SOR, SO2R, SONRR', SO2NRR', NO2, halogen, heteroaryl; and the pharmaceutical salts and stereisomers thereof. The compounds of formula (I) are potent in the treatment of neurodegenerative diseases such as Alzheimer's disease. |
申请人 |
INSA (INSTITUT NATIONAL DES SCIENCES APPLIQUÉES) DE ROUEN;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE DE ROUEN;VFP THÉRAPIES |
发明人 |
MARSAIS, FRANCIS;LEVACHER, VINCENT;PAPAMICAEL, CYRIL;BOHN, PIERRE;PEAUGER, LUDOVIC;GEMBUS, VINCENT;LE FUR, NICOLAS;DUMARTIN-LEPINE, MARIE-LAURENCE |