MARKETING N-METHYLSEROTONIN AND RELATED SUBSTANCES FOR USE IN TREATING/ LESSENING THE OCCURRENCE OF HOT FLASHES RELATED TO MENOPAUSE

摘要

Zanthoxylum piperitum (commonly known as Japanese pepper) seeds, including its mature seeds, contain the NMS precursor N-methylserotonin S-O-6-glucoside (“NMS-glucoside”) present in sufficient concentration and are metabolized with sufficient efficiency so as to provide an effective amount of NMS for use in amelioration of menopausal symptoms, including hot flashes/flushes. The Japanese pepper seeds or Japanese pepper seed extracts can also be used to enrich other sources of NMS or NMS precursors in order to provide a nutraceutical or food supplement for controlling hot flashes. This invention relates to the marketing of nutraceuticals and food supplements containing these ingredients. Target customers include perimenopausal women, menopausal women and post menopausal women who wish to reduce the risk of experiencing hot flashes.

主权项

1. A method of marketing a nutraceutical or food supplement effective in lessening the frequency of menopausal hot flashes or lessening the severity of menopausal hot flashes comprising
providing a kit comprising a nutraceutical or food supplement composition comprising an active ingredient selected from the group consisting of
a) any plant extract, regardless of species, which contains a minimum effective dose of N-methylserotonin (“NMS”), a precursor of NMS; or mixtures thereof;b) a minimum effective does of NMS or a precursor of NMS, regardless of whether the NMS is derived from a plant extract;c) a plant extracts which naturally contains NMS or a precursor of NMS, but at a less than effective dosage amount, to which additional NMS or a precursor has been added in order to bring the total amount of NMS or precursor to the effective amount;d) combinations of the above; and optionally a further ingredients useful for control of menopausal, peri-menopausal, and/or post-menopausal symptoms; wherein said kit also comprises information which informs said consumer about the benefits of the nutraceutical or food supplement for alleviating, controlling the severity, lessening the occurrence, lessening the severity or the delay of onset of hot flash symptoms associated with menopause.