Method of Targeting Hydrophobic Drugs to Vascular Lesions

摘要

This invention relates to the targeted delivery of hydrophobic drugs or combinations of hydrophobic drugs with photodynamic therapy agents to vascular lesions by complexation of the drugs to blood serum lipoproteins, which have an affinity for and accumulate in such vascular lesions.

主权项

1. A method of targeting drug delivery to a vascular lesion, comprising:
providing a core-shell carrier comprising a lipophilic shell layer that is unstable to a plasma protein; providing a non-photodynamic hydrophobic drug loaded into the core-shell carrier, and administering the drug-loaded core-shell carrier into the bloodstream of a patient in need thereof; wherein, when the core-shell carrier contacts a plasma protein in the patient's bloodstream, the core-shell carrier is disrupted, releasing the non-photodynamic hydrophobic drug which then forms a complex with a plasma protein that may be the same as or different than the plasma protein that caused the disruption of the core-shell carrier.