PCSK9-BINDING POLYPEPTIDES AND METHODS OF USE

摘要

The invention provides PCSK9-binding polypeptides and methods of using the same.

主权项

1. A PCSK9-binding polypeptide comprising the amino acid sequence:
GX1X2ECLX3NX4GGCSX5X6CX7X8LKIGYECLCPDGFQLVAQRRCE, wherein X1 is D or T; X2 is L or N; X3 is selected from the group consisting of A, D, E, H, K, L, R, S, V, and Y; X4 is L or N; X5 is selected from the group consisting of H, W, and Y; X6 is selected from the group consisting of I, L, T and V; X7 is selected from the group consisting of K, N, R and Q; and X8 is selected from the group consisting of A, D, K, N, Q and R (SEQ ID NO: 1).