GROWTH MATRICES FOR STEM CELL PROPAGATION IN VITRO AND IN TISSUE REGENERATION

摘要

The present invention provides a multifunctional 2-D and 3-D matrix for propagation of stein cells, in particular, a cliitosatv-based biomaieria! scaffold is engineered to promote CNS regeneration from primitive neural precursors by stabilizing a recombinant protein, fibroblast growth factor to preserve the cardinal properties of stem cells. The matrix, is further modified by the addition of either the extracellular matrix protein fibronectiii or the small peptide RGD or IK.VAV. A method to manu&eture an injectable multifunctional microsphere scaffold is also disclosed that is suitable as a vehicle for cell transplantation to repair traumatic brain injuries.