发明名称 |
Inhibidores heterocíclicos de glutaminil ciclasa (QC, EC 2.3.2.5) |
摘要 |
Novel heterocyclic derivatives as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water. |
申请公布号 |
ES2481823(T3) |
申请公布日期 |
2014.07.31 |
申请号 |
ES20110707182T |
申请日期 |
2011.03.10 |
申请人 |
PROBIODRUG AG |
发明人 |
HEISER, ULRICH;GAERTNER, ULF-TORSTEN;DEMUTH, HANS-ULRICH |
分类号 |
C07D403/04;A61K31/4184;A61K31/454;A61K31/4709;A61K31/5377;A61P1/04;A61P25/18;A61P25/28;A61P29/00;A61P31/04;A61P35/00;C07D401/04;C07D403/10;C07D403/14;C07D405/10 |
主分类号 |
C07D403/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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