| 主权项 |
1. A compound of Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein: Y is —N(R5)—, —N(R5)—CH2—, —CH2—N(R5)— or —CH(R5)—; each R1a and R1b is independently hydrogen, —C1-C4 alkyl, —N(R7)(C1-C4 alkylene)-N(R7)(C1-C4 alkyl), aryl, heteroaryl, heterocyclyl, —C(O)N(R7)-aryl, —N(R7)C(O)-aryl, —(C1-C4 alkylene)-aryl, —(C1-C4 alkylene)-heteroaryl, —O—(C0-C4 alkylene)-aryl, —O—(C0-C4 alkylene)-heteroaryl, —O—(C0-C4 alkylene)-heterocyclyl, —O—(C0-C4 alkylene)-carbocyclyl, —N(R7)-aryl, or —N(R7)-heteroaryl, —N(R9)-aryl, —N(R9)-heteroaryl, —O—(C1-C4 alkeylene)-N(R7)C(O)O—(C1-C4 alkylene)-aryl, —N(R9)—C(O)—(C2-C4 alkenyl) wherein: at least one of R1a and R1b is not hydrogen or methyl; any alkylene moiety present in R1a or R1b is optionally substituted with OH or F; each R7 is independently selected from hydrogen and C1-C4 alkyl; and any aryl, heteroaryl, or heterocyclyl of R1a or R1b is optionally substituted with one or more substituents selected from -G-L-M, halo, —NO2, C1-C6 alkyl, —C≡N, ═O, —CF3 and —OCF3; G is a bond or a bivalent C1-C6 saturated or unsaturated, straight or branched hydrocarbon chain wherein optionally one, two or three methylene units of the hydrocarbon chain are independently replaced by —NR8—, —O—, —C(O)—, —OC(O)—, —C(O)O—, —S—, —SO—, —SO2—, —C(═S)—, —C(═NR8)—, —N═N—, or —C(═N2)—; L is a covalent bond or a bivalent C1-8 saturated or unsaturated, straight or branched, hydrocarbon chain, wherein one, two, or three methylene units of L are optionally and independently replaced by cyclopropylene, —N(R8)C(O)—, —C(O)N(R8)—, —N(R8)SO2—, SO2N(R8)—, —O—, —C(O)—, —OC(O)—, —C(O)O—, —S—, —SO—, —SO2—, —C(═S)—, —C(═NR8)—, —N═N—, or —C(═N2)—; M is E, or a 3-10 membered monocyclic or bicyclic, saturated, partially unsaturated, or aromatic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and wherein said ring is substituted with at 1-4 groups independently selected from -D-E, oxo, NO2, halogen, CN, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl; D is a covalent bond or a bivalent C1-C6 saturated or unsaturated, straight or branched, hydrocarbon chain, wherein one or two methylene units of D are optionally and independently replaced by —NR8—, —S—, —O—, —C(O)—, —SO—, or —SO2—; E is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, wherein said alkyl, alkenyl or alkynyl is optionally substituted with oxo, halogen, or CN; and each R8 is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, —C1-C6 alkoxy, —S(O)2—C2-C4 alkenyl, or an optionally substituted group selected from phenyl, a 4-7 membered heterocyclyl having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R2 is selected from phenyl, a 3-7 membered cycloalkyl, C2-C4 alkyl, or CF3, wherein the phenyl or cycloalkyl is optionally substituted with a substituent selected from methyl or fluoro; each R3 is independently selected from halo, —(C1-C4 alkylene)-O—(C1-C4 alkyl), —C1-C4 fluoroalkyl, —C(O)—O—(C1-C4 alkyl), -phenyl, -heteroaryl, C3-C7 cycloalkyl, —CH2—N(C1-C4 alkyl)2, C(O)—N—(C1-C4 alkyl)2, —C(O)—NH—(C1-C4 alkyl), —C1-C4 alkyl optionally substituted with one or more halo or —OH, or two R3s are taken together to form a 3-8 saturated ring or a fused phenyl wherein said saturated ring or fused phenyl is optionally substituted with 1 to 2 methyl; R4 is selected from hydrogen, —CN, halo, C1-C4 alkoxy, —CH2NH(C1-C4 alkyl), C2-C4 alkenyl, C2-C4 alkynyl, —(C1-C4 alkyl)-O—(C1-C4 alkyl), C1-C4 fluoroalkyl, C(O)—N—(C1-C4 alkyl)2, —C(O)—NH—(C1-C4 alkyl), —C(O)—O—(C1-C4 alkyl), —C(O)—OH, —S(O)2—(C1-C4 alkyl), and a 5-membered heteroaryl; R5 is selected from: —C(O)—(C1-C5 alkyl), —C(O)—(C2-C6 alkenyl), —C(O)—(C0-C2 alkylene)-Q, —C(O)—(C1-C4 alkenylene)-Q, —C(O)—(C0-C2 alkylene)-N(R6)—(C0-C2 alkylene)-Q, —C(O)—O—(C0-C2 alkylene)-Q, —C(O)—(C1-C2 alkylene)-O—(C0-C2 alkylene)-Q, —C(O)—C(O)-Q, —S(O)2-Q, —C(O)—(C1-C4 alkylene)-O—C(O)—(C1-C4 alkyl), —C(O)—(C1-C4 alkylene)-C(O)—O—(C1-C4 alkyl), —C(O)—N(R6)—(C1-C4 alkylene)-O—C(O)—(C1-C4 alkyl), —C(O)—N(R6)—(C1-C4 alkylene)-C(O)—O—(C1-C4 alkyl), —C(O)—(C0-C2 alkylene)-N(R6)—(C1-C6 alkyl), —C(O)—(C0-C2 alkylene)N(R6)—(C2-C6 alkynyl), —C(O)—(C0-C2 alkylene)-N(R6)—(C2-C6 alkenyl), —C(O)—(C0-C2 alkylene)-N(R6)—(C0-C2 alkylene)-O—(C1-C4 alkyl), —C(O)—(C1-C2 alkylene)-O—(C1-C4 alkyl), —C(O)—(C1-C2 alkylene)-C(O)C(O)N(R)(C1-C4 alkyl), —C(O)—O—(C1-C4 alkylene)-O—(C1-C4 alkyl), —(C0-C4 alkylene)-O—C(O)—(C1-C4 alkyl), —(C0-C4 alkylene)-C(O)—O—(C1-C4 alkyl), —(C0-C4 alkylene)-O—(C1-C4 alkyl), —C(O)—(C1-C2 alkylene)-S(O)0-2-(C1-C4 alkyl), —S(O)2—(C1-C4 alkyl), —C(O)—(C1-C4 alkylene)-C(O)C(O)N(R6)(C1-C6 alkyl), —C(O)—(C1-C4 alkylene)-N(R6)S(O)2—(C1-C6 alkyl), or —C(O)—(C1-C4 alkylene)-N(R6)S(O)2Q, wherein: any alkylene moiety present in R5 is optionally substituted with OCH3, OH or F; any terminal methyl moiety present in R5 is optionally replaced with —CH2OH, CF3, CH2F, —CH2Cl, C(O)CH3, C(O)CF3, CN, —OCH3, —C(O)H, —OP(O)(OH)2, —OP(O)(C1-C4 alkoxy)2 or CO2H; each R6 is independently selected from hydrogen and methyl; Q is selected from aryl, heteroaryl, carbocyclyl and heterocyclyl, wherein Q is optionally substituted with up to 3 substituents independently selected from C1-C4 alkyl optionally substituted with OH, C1-C4 alkoxy, —C(O)O—(C1-C4 alkyl), —(C1-C4 alkylene)-(C1-C4 alkoxy), —CN, —OH, fluoro, chloro, and bromo; R9 is selected from aryl and heteroaryl, wherein each aryl or heteroaryl is optionally substituted with one or more substituents selected from -G-L-M, halo, C1-C6 alkyl, —C≡N, ═O, —CF3 and —OCF3; and m is 0, 1, 2 or 3. |
