The controlled release method for a pharmaceutical composition composed of chelating complex micelles

摘要

This invention provides the controlled-release method for a pharmaceutical composition comprising of metals in the drug carrier. The specific chelator is used to trigger the release of active pharmaceutical ingredients from chelating complex micelles. The drug release rate and half-life can also be controlled by manipulating the dosing sequence and the concentration of metal and specific chelator.

主权项

1. A controlled-release method for manipulating drug release, comprising administrations of:
a chelating complex micelles comprise at least a drug molecule, a polymer ligand, and a metal core; and at least one selected from: a metal chelator, wherein corresponds to the metal core of chelating complex micelles, and a metal, wherein as the same as the metal core of the chelating complex micelles.