| 发明名称 |
PHARMACEUTICAL COMPOSITION WITH IMPROVED BIOAVAILABILITY |
| 摘要 |
The invention relates to solid dispersions of poorly water soluble compounds, in particular 4-{[(2R, 3S, 4R, 5S)-4-(4-chloro-2-Fluorophenyl)-3-(3-chloro-2-Fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-pyrrolidine-2-carbonyl]amino}-3- Methoxy-Benzoic Acid, formed by solvent co-precipitation or spray drying, resulting in improved bioavailability, safety and tolerability of said compounds. |
| 申请公布号 |
CA2892025(A1) |
申请公布日期 |
2014.07.31 |
| 申请号 |
CA20142892025 |
申请日期 |
2014.01.20 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
LOMUSCIO, STEVE;MA, HUA;MATCHETT, MICHAEL ALLEN;SANDHU, HARPREET K.;SHAH, NAVNIT HARGOVINDAS;ZHANG, YU-E |
| 分类号 |
A61K31/40;A61K9/10;A61K9/14;A61K9/16;A61K47/32;A61K47/36;A61K47/38;A61P35/00 |
主分类号 |
A61K31/40 |
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