发明名称 |
IMPLANTABLE-GLUCOSE RESPONSIVE INSULIN DELIVERY DEVICE |
摘要 |
A biocompatible insulin delivery device is provided comprising an insulin reservoir sealed with a glucose-responsive plug or membrane. The plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to hypoglycemic glucose concentration. In one embodiment, the plug is made of a biocompatible polymeric matrix comprising an inorganic component, a stimulus-responsive component and a catalytic component. |
申请公布号 |
US2014213963(A1) |
申请公布日期 |
2014.07.31 |
申请号 |
US201414230971 |
申请日期 |
2014.03.31 |
申请人 |
The Governing Council of the University of Toronto |
发明人 |
Wu Xiao Yu;Zhang Kai;Huang Huiyu;Gordijo Claudia;Li Jason Siu-Wei;Chu Michael K.L. |
分类号 |
A61L31/04 |
主分类号 |
A61L31/04 |
代理机构 |
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代理人 |
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主权项 |
1. A biocompatible insulin delivery device comprising a reservoir for insulin, a glucose-responsive plug that seals the reservoir, and optionally comprising a protective microporous membrane covering the exposed surface of the glucose-responsive plug and further sealing the reservoir, wherein the plug comprises a polymeric matrix having an inorganic component and a stimulus-responsive component adapted to alter the porosity of the plug in response to a stimulus and wherein the plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to a hypoglycemic glucose concentration. |
地址 |
Toronto CA |