METHODS AND COMPOSITIONS FOR ENHANCED DELIVERY OF MACROMOLECULES

摘要

The invention provides compositions and methods that enhance the delivery of large macromolecules (i.e., greater than 10 kDa), such as antigen-binding polypeptides, across tight junctions. Such methods and compositions are particularly useful for delivering therapeutic antigen-binding polypeptides to the CNS, via intranasal administration, for the treatment of neurological disorders.

主权项

1. A method for selective intranasal delivery of an antigen-binding polypeptide to the central nervous system of a patient, the method comprising administering to a patient in need thereof a composition comprising a penetration enhancer and an antigen-binding protein, wherein the penetration enhancer is Pz-peptide.