主权项 |
1. A method of labeling, imaging and detecting beta-amyloid (Aβ) peptides, oligomers and fibrils using carbazole-based fluorophores comprising a formula S or V series: wherein Ar is a heteraromatic ring selected from the group consisting of pyridinyl, substituted pyridinyl, quinolinyl, substituted quinolinyl, acridinyl, substituted acridinyl, benzothiazolyl, substituted benzothiazolyl, benzoxazolyl, and substituted benzoxazolyl; R1 is selected from the group consisting of polyethylene glycol chain, alkyl, substituted alkyl, peptide chain, glycosidyl, and C(O)NHCH((CH2CH2O)2CH3)2; R2 is selected from the group consisting of ethenyl, ethynyl, azo and azomethinyl. R3 is selected from the group consisting of alkyl, HO-alkyl, HS-alkyl, H2N-alkyl, HN-alkyl-alkyl, HOOC-alkyl, (alkyl)3N+-alkyl, and (Ph)3P+-alkyl; and X is an anion selected from the group consisting of F−, Cl−, Br−, I−, HSO4−, H2PO4−, HCO3−, tosylate, and mesylate. |