| 摘要 |
<p>The propellane derivatives represented by general formula (I) or pharmaceutically-acceptable acid addition salts thereof, or hydrates or solvates of said propellane derivatives and acid addition salts are used as analgesics, antidepressants and anxiolytics. (In the formula: R1 represents a cycloalkyl alkyl (the number of carbon atoms in the cycloalkyl moiety is 3 to 6, and the number of carbon atoms in the alkyl moiety is 1 to 5), an aralkyl (the number of carbon atoms in the aryl moiety is 6 to 10, and the number of carbon atoms in the alkylene moiety is 1 to 5), or the like; R2 represents a hydroxy or the like; R3 represents hydrogen, a C1-6 alkyl, or an aralkyl (the number of carbon atoms in the aryl moiety is 6 to 10, and the number of carbon atoms in the alkylene moiety is 1 to 5); X is CH2, C=O, or the like; and Y represents a C6-10 aryl or a heteroaryl (wherein 1 to 4 heteroatoms selected from N, O and S are included as ring atoms). Moreover, the double lines comprising solid lines and a dotted line represent single or double bonds.)</p> |
