| 摘要 |
A process for the production of 1R,2S-methoxamine, which comprises adding trifluoroacetic acid dropwise to a solution comprising (S)-amino-1-(2,5-dimethoxyphenyl)-1-propanone, the amino group of which is protected, and dimethylphenylsilane and removing the protecting group from the resulting amino-protected(1R,2S)-2-amino-1-(2,5-dimethoxy-phenyl)-1-propanol. Also claimed are 1R,2S-methoxamine or a physiologically tolerable salt thereof for use as a medicament, and a pharmaceutical composition comprising 1R,2S-methoxamine or a physiologically tolerable salt thereof in admixture or conjunction with a pharmaceutically suitable carrier. |
