发明名称 |
N-TERMINAL TRUNCATED INSULIN ANALOGUES |
摘要 |
An insulin analogue contains a foreshortened B-chain polypeptide lacking residues B1-B3 and optionally contains an additional substitution in the C-terminal B23-B30 segment of the B-chain. The insulin analogue lacking residues B1-B3 may contain substitutions at B28 and/or B29 that confer rapid action and optionally a non-standard substitution at B24. The analogue may be an analogue of a mammalian insulin, such as human insulin. A nucleic acid encoding such an insulin analogue is also provided. A method of treating a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. A method of semi-synthesis is provided using an unprotected octapeptide by means of modification of an endogenous tryptic site by non-standard amino-acid substitutions. |
申请公布号 |
CA2937532(A1) |
申请公布日期 |
2014.07.31 |
申请号 |
CA20142937532 |
申请日期 |
2014.01.22 |
申请人 |
CASE WESTERN RESERVE UNIVERSITY |
发明人 |
WEISS, MICHAEL |
分类号 |
A61K38/28;C07K14/62;C12P21/06 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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