Novel bi-specific monoclonal antibody with advanced anti-cancer activity and pharmaceutical composition for treating cancer comprising the same

摘要

PURPOSE: A novel bispecific monoclonal antibody and a composition for cancer treatment including the same with improved anticancer activities are provided to express improved antibody dependent cellular cytotoxicity. CONSTITUTION: A novel bispecific monoclonal antibody comprises an antibody which combines with the cancer cell surface antigen and a domain which combines with immunocyte surface antigen. A domain which binds with the immunocyte surface antigen is connected with linker at the C-terminal of Fc domain in antibody which binds with the cancer cell surface antigen. The antibody bonded with the cancer cell surface antigen is in IgG form. The domain bonded with the immunocyte surface antigen is in scFv(Single-chain variable fragment) form. The linker is peptide. The linker peptide has the sequence number 4(SEQ ID NO:4).