| 摘要 |
<p>The invention relates to compounds of formula (I), where R1, L and m have the denotations as defined in the claims, and/or to the physiologically harmless salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of formula (I) can be used for inhibiting serine/threonine protein kinases and for sensitizing cancer cells to anticancer drugs and/or ionizing radiation. A further object of the invention is the use of the compounds of formula (I) in the prophylaxis, therapy or progress monitoring of cancers, tumors, metastases, or angiogenic disorders, in combination with radiotherapy and/or an anticancer drug. The invention further relates to a method for producing the compounds of formula (I) by reacting compounds of formulae (II) and (III) and, if need be, converting a chemical base or acid of the compounds of the formula (I) to one of the salts thereof.</p> |
