发明名称 |
METHOD TO PREDICT THE PRESENCE OF INFLAMMATION OR ITACONIC ACID, IRG1 AND/OR PROTEIN IRG1 IN A SUBJECT AND PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING INFLAMMATION |
摘要 |
<p>The present invention is directed to in vitro methods to predict the presence of inflammation, gene IRG1 or protein encoded by IRG1 in a subject by determining presence of itaconic acid in a biological sample isolated from the subject. The invention is also directed to methods to predict the ability of a subject to produce itaconic acid under inflammation by determining the presence IRG1 in a biological sample. The invention is also related to pharmaceutical composition to initiate production of itaconic acid in a subject for preventing or treating inflammation, or bacterial infection.</p> |
申请公布号 |
EP2758069(A2) |
申请公布日期 |
2014.07.30 |
申请号 |
EP20120762585 |
申请日期 |
2012.09.21 |
申请人 |
UNIVERSITÉ DU LUXEMBOURG |
发明人 |
HILLER, KARSTEN;MICHELUCCI, ALESSANDRO;CORDES, THEKLA;WEGNER, ANDRE;GHELFI, JENNY;BALLING, RUDI |
分类号 |
A61K38/19;A61K48/00;C12Q1/68;G01N33/50;G01N33/68 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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