发明名称 |
GENETIC MARKER FOR THE DIAGNOSIS OF DEMENTIA WITH LEWY BODIES |
摘要 |
Specific polymorphisms in BChE gene have been found which allow determining whether a patient suffers from dementia with Lewy bodies (DLB), and allow distinguishing it from Alzheimer's disease. The invention provides an in vitro method for the diagnosis of DLB comprising determining in a biological sample from a subject, the genotype of the following polymorphisms in butyrylcholinesterase (BChE) gene: the polymorphic site at position 3687 in NCBI Accession Number NG_009031 (i.e. SEQ ID NO: 1) the polymorphic site at position 4206 in SEQ ID NO: 1, the polymorphic site at position 4443 in SEQ ID NO: 1. and the polymorphic site at position 68974 in NCBI Accession Number NG_009031 (i.e. position 934 in SEQ ID NO: 26). |
申请公布号 |
KR20140094675(A) |
申请公布日期 |
2014.07.30 |
申请号 |
KR20147005154 |
申请日期 |
2012.07.30 |
申请人 |
UNIVERSITAT AUTONOMA DE BARCELONA;FUNDACI&OACUTE, INSTITUT D'INVESTIGACI&OACUTE, ENCI&EGRAVE,NCIES DE LA SALUT GERMANS TRIAS I PUJOL |
发明人 |
BEYER KATRIN;DOMINGO MONTSERRAT;ARIZA AURELIO |
分类号 |
C12Q1/68;G01N33/53 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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