Oxidisable pyridine derivatives, their preparation and use as anti-Alzheimer agents

摘要

A compound of the formula (I) in which the dotted lines indicate the presence of at least one double bond; n = 0 to 4; R 3 and R 4 are H, or when n = 1, R 3 and R 4 can also form together a double bond between the carbon atoms, and m = 0, 1 or 2, Z is CH or N or Z is C and -CHR 3 - is =CH- linked by the double bond to the cyclopentanone; or -(-) m - is absent, and Z is NH, >N-alkyl, >N-phenyl, >N-benzyl or >N-heteroaryl; R 8 is alkyl, aryl or heteroaryl which can be optionally substituted; EWG represents an electron withdrawing group selected from the group comprising COOR, COSR, CONRR', CN, COR, CF 3 , SOR, SO 2 R, SONRR', SO 2 NRR', NO 2 , halogen, heteroaryl; and the pharmaceutical salts or tautomers thereof. The compounds of formula (I) are potent in the treatment of neurodegenerative diseases such as Alzheimer's disease.