INFLUENZA VIRUS MUTANT EXPRESSING A HAEMAGGLUTININ PROTEIN WITHOUT FUNCTIONAL SIGNAL SEQUENCE FOR USE AS VACCINE

摘要

The present invention provides a modified influenza virus wherein the RNA of the haemagglutinin gene has been modified such that the haemagglutinin signal sequence is not expressed and the virus produces a haemagglutinin protein that lacks a functional signal sequence. The invention further provides composition comprising the modified virus and uses of the modified virus.