| 主权项 |
1. An isolated antibody or an antigen-binding fragment thereof that specifically binds to IL-17A and IL-17F and inhibits the biological function of both IL-17A and IL-17F, comprising a light chain variable domain comprising CDRL1, CDRL2, and CDRL3 regions, and a heavy chain variable domain comprising CDRH1, CDRH2, and CDRH3 regions, wherein
(a) CDRL1 comprises the sequence DVSTAVA (SEQ ID NO:24), CDRL2 comprises the sequence SASFLYS (SEQ ID NO:26), and CDRL3 comprises the sequence SYTTPPT (SEQ ID NO:28), and CDRH1 comprises the sequence of GFTFTDYDIS (SEQ ID NO:35), CDRH2 comprises the sequence of SDGYTYYADSVKG (SEQ ID NO:37), and CDRH3 comprises the sequence YLYWSYV (SEQ ID NO:40); or (b) CDRL1 comprises the sequence VISSSLA (SEQ ID NO:33), CDRL2 comprises the sequence GASFFYS (SEQ ID NO:96), and CDRL3 comprises the sequence HNDLPLT (SEQ ID NO:32), and CDRH1 comprises the sequence of GFTFTDYDIS (SEQ ID NO:35), CDRH2 comprises the sequence SDGYTYYADSVKG (SEQ ID NO:37), and CDRH3 comprises the sequence YLYWSYV (SEQ ID NO:40). |
