Methods for treating disease using an anti-IL-21 receptor antibody

摘要

Monoclonal antibodies to the IL-21 receptor and multimeric complexes comprising the IL-21 receptor; including monoclonal antibodies to the heterodimeric receptor, IL-21/IL-2Rγ; have been prepared. The invention also describes a method of producing said antibodies. And, the invention also describes a method of treatment comprising using said antibodies to suppress an immune response.

主权项

1. A method of treating an inflammatory or autoimmune disease in a subject, wherein the disease is selected from the group consisting of an inflammatory bowel disease (IBD), systemic lupus erythematosus, rheumatoid arthritis, psoriasis, psoriatic arthritis, graft vs. host disease (GVHD), Sjogren's syndrome, scleroderma, and multiple sclerosis, the method comprising:
administering to the subject a therapeutically effective amount of an anti-IL-21 receptor antibody, wherein said antibody is a humanized antibody derived from the monoclonal antibody produced by the hybridoma designated ATCC Accession NO. PTA-7141.