发明名称 |
Cortistatin A analog and use thereof |
摘要 |
A compound represented by the general formula (M):;(wherein R1 represents a substituted or unsubstituted aromatic heterocyclic group,R2 represents a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 3 carbon atoms, OR3, N(R3)2, C(═O)OR3 or C(═O)N(R3)2,R3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 4 carbon atoms,R4 represents a hydrogen atom, an oxygen atom or OR5, andR5 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or an acyl group having 1 to 3 carbon atoms); ora pharmaceutically acceptable salt thereof is a cortistatin A analog which is useful as an active ingredient of medicaments for cancer prevention or treatment in that the analog can be mass-produced by chemical synthesis due to its simple chemical structure and retains the same biological activities as those of cortistatin A. |
申请公布号 |
US8791263(B2) |
申请公布日期 |
2014.07.29 |
申请号 |
US201113823265 |
申请日期 |
2011.09.16 |
申请人 |
Osaka University |
发明人 |
Kobayashi Motomasa;Kotoku Naoyuki;Arai Masayoshi;Tamura Satoru |
分类号 |
C07D405/04;C07D217/02;A61K45/00;A61K31/4725;A61P43/00;A61P35/00;C07D407/10;C07F7/18;A61K45/06 |
主分类号 |
C07D405/04 |
代理机构 |
Wenderoth, Lind & Ponack, L.L.P. |
代理人 |
Wenderoth, Lind & Ponack, L.L.P. |
主权项 |
1. A compound represented by the general formula (M): wherein R1 represents a pyridyl group, a quinolyl group or an isoquinolyl group, R2 represents a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 3 carbon atoms, OR3, N(R3)2, C(═O)OR3 or C(═O)N(R3)2, R3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 4 carbon atoms, R4 represents a hydrogen atom, an oxygen atom or OR5, and R5 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or an acyl group having 1 to 3 carbon atoms, and is a single bond or double bond, with proviso that when a partial formula R4 is ═R4, a partial formula and when a partial formula a partial formula R4 is —R4; or a pharmaceutically acceptable salt thereof. |
地址 |
Osaka JP |