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1. A compound of the formulawherein
A denotes a group of the formula wherein m denotes the number 1 or 2, R6a independently of one another denotes a hydrogen, fluorine, chlorine or bromine atom or a C1-3-alkyl, hydroxy, amino, C1-3-alkylamino, di-(C1-3-alkyl)-amino, aminocarbonyl, C1-3-alkylaminocarbonyl, di-(C1-3-alkyl)-aminocarbonyl or C1-3-alkylcarbonylamino group and R6b independently of one another may be a hydrogen atom, a C1-4-alkyl, C1-4-alkylcarbonyl, C1-4-alkyloxycarbonyl or C1-3-alkylsulphonyl group, with the proviso that
in the above-mentioned substituted 7-membered groups A the heteroatoms optionally introduced as substituents are not separated from another heteroatom by precisely one carbon atom, or a group of the formula wherein
m denotes the number 1 or 2,X1 denotes an oxygen atom or a methylene, —NR6b—, carbonyl or sulphonyl group,X2 denotes an oxygen atom or a —NR6b group,X3 denotes a methylene, carbonyl or sulphonyl group,X4 denotes an oxygen or sulphur atom, a —NR6b or carbonyl group,X5 denotes a carbonyl or sulphonyl group,X6 denotes an oxygen atom, a —NR6b or methylene group,X7 denotes an oxygen or sulphur atom or a —NR6b group,X8 denotes a methylene or carbonyl group,X9 denotes a —NR6b or carbonyl group,X10 denotes a sulphinyl or sulphonyl group andR6a independently of one another denote a hydrogen, fluorine, chlorine or bromine atom or a C1-3-alkyl, hydroxy, amino, C1-3-alkylamino, di-(C1-3-alkyl)-amino, aminocarbonyl, C1-3-alkylaminocarbonyl, di-(C1-3-alkyl)-aminocarbonyl or C1-3-alkylcarbonylamino group andR6b independently of one another may be a hydrogen atom, a C1-4-alkyl, C1-4-alkylcarbonyl, C1-4-alkoxycarbonyl or C1-3-alkylsulphonyl group, with the proviso that
in the above-mentioned substituted 7-membered groups A the heteroatoms optionally introduced as substituents are not separated from another heteroatom by precisely one carbon atom, R1 denotes a hydrogen, fluorine, chlorine or bromine atom, a C1-3-alkyl group wherein the hydrogen atoms may be wholly or partly replaced by fluorine atoms, a C2-3-alkenyl, C2-3-alkynyl, nitro, amino, C1-3-alkoxy, a mono-, di- or trifluoromethoxy group, R2 denotes a hydrogen, fluorine, chlorine or bromine atom or a C1-3-alkyl group, R3 denotes a hydrogen atom, a C2-3-alkenyl or C2-3-alkynyl group or a straight-chain or branched C1-6-alkyl group wherein the hydrogen atoms may be wholly or partly replaced by fluorine atoms, and which is optionally substituted by a nitrile, hydroxy, a C1-5-alkyloxy group wherein the hydrogen atoms may be wholly or partly replaced by fluorine atoms, an allyloxy, propargyloxy, benzyloxy, C1-5-alkylcarbonyloxy, C1-5-alkyloxycarbonyloxy, carboxy-C1-3-alkyloxy, C1-5-alkyloxycarbonyl-C1-3-alkyloxy, C1-8-alkyloxycarbonylamino, mercapto, C1-3-alkylsulphanyl, C1-3-alkylsulphinyl, C1-3-alkylsulphonyl, C1-3-alkylcarbonylamino-C1-3-alkylsulphanyl, C1-3-alkylcarbonylamino-C1-3-alkylsulphinyl, C1-3-alkylcarbonylamino-C1-3-alkylsulphonyl, carboxy, C1-3-alkyloxycarbonyl, allyloxycarbonyl, propargyloxycarbonyl, benzyloxycarbonyl, aminocarbonyl, C1-3-alkylaminocarbonyl, di-(C1-3-alkyl)-aminocarbonyl, C3-6-cycloalkyleneiminocarbonyl, aminosulphonyl, C1-3-alkylaminosulphonyl, di-(C1-3-alkyl)-aminosulphonyl, C3-6-cycloalkyleneiminosulphonyl, amino, C1-3-alkylamino, di-(C1-3-alkyl)-amino, C1-5-alkylcarbonylamino, C1-3-alkylsulphonylamino, N-(C1-3-alkylsulphonyl)-C1-3-alkylamino, C3-6-cycloalkylcarbonylamino, aminocarbonylamino, C1-3-alkylaminocarbonylamino, di-(C1-3-alkyl)-aminocarbonylamino, a 4- to 7-membered cycloalkyleneiminocarbonylamino, benzyloxycarbonylamino, phenylcarbonylamino or guanidino group, a carboxy, aminocarbonyl, C1-4-alkylaminocarbonyl, C3-6-cycloalkylaminocarbonyl, di-(C1-3-alkyl)-aminocarbonyl, C1-4-alkoxycarbonyl, C4-6-cycloalkyleneiminocarbonyl group, a phenyl or heteroaryl, phenylcarbonyl-C1-3-alkyl, phenyl-C1-3-alkyl or heteroaryl-C1-3-alkyl group which is optionally mono- or polysubstituted in the phenyl or heteroaryl moiety by fluorine, chlorine or bromine atoms, C1-3-alkyl, amino, C1-3-alkylamino, di-(C1-3-alkyl)-amino, hydroxy, C1-4-alkyloxy, mono-, di- or trifluoromethoxy, benzyloxy, carboxy-C1-3-alkyloxy, C1-3-alkyloxycarbonyl-C1-3-alkyloxy, aminocarbonyl-C1-3-alkyloxy, C1-3-alkylaminocarbonyl-C1-3-alkyloxy, di-(C1-3-alkyl)-aminocarbonyl-C1-3-alkyloxy, a 4-to 7-membered cycloalkyleneiminocarbonyl-C1-3-alkoxy, carboxy, C1-3-alkyloxycarbonyl or C1-3-alkyloxy-carbonylamino group, a 3- to 7-membered cycloalkyl, cycloalkyleneimino, cycloalkyl-C1-3-alkyl or cycloalkyleneimino-C1-3-alkyl group wherein in the cyclic moiety a methylene group may be replaced by an —NH— group optionally substituted by a C1-3-alkyl or C1-3-alkylcarbonyl group or by an oxygen atom and wherein additionally a methylene group adjacent to the —NH—, —N(C1-3-alkylcarbonyl)- or —N(C1-3-alkyl)- group may be replaced in each case by a carbonyl or sulphonyl group, with the proviso that a cycloalkyleneimino group as hereinbefore defined wherein two nitrogen atoms are separated from one another by precisely one —CH2— group is excluded, R4 denotes a hydrogen atom or a C1-3-alkyl group or R3 and R4 together with the carbon atom to which they are bound, denote a C3-7-cycloalkyl group, while
one of the methylene groups of the C3-7-cycloalkyl group may be replaced by an imino, C1-3-alkylimino, acylimino or sulphonylimino group, R5 denotes a hydrogen atom or a C1-3-alkyl group, B denotes a group of formula wherein
n denotes the number 1 or 2,R7 denotes a hydrogen atom or a C1-3-alkyl, hydroxy, C1-5-alkyloxycarbonyl, carboxy-C1-3-alkyl, C1-3-alkyloxycarbonyl-C1-3-alkyl, amino or C1-3-alkylamino group andR8 independently of one another denote a hydrogen, fluorine, chlorine, bromine or iodine atom, a C1-3-alkyl group wherein the hydrogen atoms may be wholly or partly replaced by fluorine atoms, a C2-3-alkenyl or C2-3-alkynyl, a hydroxy, C1-3-alkoxy, trifluoromethoxy, amino, nitro or nitrile group, while, unless otherwise stated, by the term “heteroaryl group” mentioned hereinbefore in the definitions is meant a monocyclic 5- or 6-membered heteroaryl group, while
the 6-membered heteroaryl group contains one, two or three nitrogen atoms andthe 5-membered heteroaryl group contains an imino group optionally substituted by a C1-3-alkyl, phenyl or phenyl-C1-3-alkyl group, an oxygen or sulphur atom oran imino group optionally substituted by a C1-3-alkyl, phenyl, amino-C2-3-alkyl, C1-3-alkylamino-C2-3-alkyl, di-(C1-3-alkyl)-amino-C2-3-alkyl, a 4- to 7-membered cycloalkyleneimino-C1-3-alkyl or phenyl-C1-3-alkyl group or an oxygen or sulphur atom and additionally a nitrogen atom oran imino group optionally substituted by a C1-3-alkyl or phenyl-C1-3-alkyl group and two or three nitrogen atoms, and moreover a phenyl ring optionally substituted by a fluorine, chlorine or bromine atom, a C1-3-alkyl, hydroxy, C1-3-alkyloxy group, amino, C1-3-alkylamino, di-(C1-3-alkyl)-amino or C3-6-cycloalkyleneimino group may be fused to the above-mentioned monocyclic heteroaryl groups via two adjacent carbon atoms
and the bond is effected via a nitrogen atom or a carbon atom of the heterocyclic moiety or a fused-on phenyl ring, while the alkyl and alkoxy groups contained in the above-mentioned definitions which have more than two carbon atoms may, unless otherwise stated, be straight-chain or branched and the alkyl groups in the previously mentioned dialkylated groups, for example the dialkylamino groups, may be identical or different, and the hydrogen atoms of the methyl or ethyl groups contained in the foregoing definitions may be wholly or partly replaced by fluorine atoms, or a tautomer or salt thereof. |
