| 发明名称 | Conjugates of synthetic TLR agonists and uses therefor | ||
| 摘要 | The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma. | ||
| 申请公布号 | US8790655(B2) | 申请公布日期 | 2014.07.29 |
| 申请号 | US201313736545 | 申请日期 | 2013.01.08 |
| 申请人 | The Regents of The University of California | 发明人 | Carson Dennis A.;Cottam Howard B.;Wrasidlo Wolfgang;Wu Christina C. N.;Daniels Gregory A. |
| 分类号 | A61K39/385;A61K45/00;A61K47/00;A61K9/127;A01N43/90;A61K31/522;C07D473/00 | 主分类号 | A61K39/385 |
| 代理机构 | Schwegman Lundberg & Woessner, P.A. | 代理人 | Schwegman Lundberg & Woessner, P.A. |
| 主权项 | 1. A method for inducing an immune response in a mammal comprising: administering to a mammal a compound of formula A in an amount effective to induce an immune response in the mammal, the compound of formula A having the structure:or a pharmaceutically acceptable salt thereof, wherein: X1 is —O—; R1 is hydrogen, (C1-C10)alkyl or (C1-C10)alkyl substituted with (C1-C6)alkoxy; X2 is C(O); and R3 is dioleoylphosphatidyl ethanolamine (DOPE). | ||
| 地址 | Oakland CA US | ||