| 主权项 |
1. A compound of formula (I): wherein: R1 denotes —CO2R3, —CON(H)2-p(A)p, —N(H)(CH2)nCO2R3, —N(R3)(CH2)nCO2R3, —NH—CO-A, Hal, —CF3, —OCF3, —OH, —OA, —CN, or —NO2, —(CH2)sN(H)2-p(A)p, —CH(CH3)(CH2)nN(H)2-p(A)p, —CH(R3)(CH2)nN(H)2-p(A)p, —(CH2)sN(R3)(CH2)nCO2R3, —(CH2)sNH—CO-A, —(CH2)nN(R3)2, —CH(CH3)(CH2)nN(R3)CH(CH3)(CH2)nCO2R3, or —CH(R3)(CH2)nN(R3)CH(R3)(CH2)nCO2R3, or when in position meta or para to the oxadiazole ring, R1 also denotes —N(H)2-p(A)p or A, R2 is H, Hal, —CN, —NO2, —OH, OA, —CO2R3, —CON(H)2-p(A)p, —N(H)(CH2)nCO2R3, —NH—CO-A, —CF3, or —OCF3, or when in position meta or para to the oxadiazole ring, R2 also denotes —N(H)2-p(A)p or A, Ra and Rb are independently from each other A, —CF3, Hal, —CH2—OR3, OR3, —OCF3, (C1-C7)alkyl, —(CH2)nO(CH2)nOMe or CH(CH3)OCH3, W, Y are independently from each other CH, Z denotes Ar, A is branched or linear alkyl having 1 to 12 C-atoms, wherein one or more H-atoms are optionally substituted Hal, OR3, CN, CO2R3 or N(R3)2 and wherein one or more non-adjacent CH2-groups are optionally substituted by O, NR3 or S and/or by —CH═CH— or —C≡C— groups, or A denotes a cycloalkyl or cycloalkylalkylene having 3-7 ring C atoms, Ar denotes a monocyclic or bicyclic, aromatic carbocyclic ring having 6 carbon atoms, which is unsubstituted, monosubstituted, disubstituted or trisubstituted by Hal, —CF3, —OCF3, —NO2, —CN, perfluoroalkyl, A, OA, —OH, —NH2, —COH, —COOR3, —CONH2, —CON(H)2-qAq, —NR3(CH2)nCOA, —NR3(CH2)nCOOA, —NR3(CH2)nCOR3, —N(H)2-qAq, —NHSO2A, —NHSO2—N(H)2-m(A)m, —N(H)1-qAqCOA, —N(H)1-qAqSO2—N(H)2-m(A)m, —N(H)1-qAqCON(H)2-m(A)m, —COOA, —SO2A, —SO2N(H)2-m(A)m, or —(CH2)nOR3, Hal is F, Cl, Br or I, R3 is H or A, m is 0, 1 or 2, p is 0, 1 or 2, q is 0 or 1, s is 1, 2, 3, 4 or 5, n is 0, 1, 2, 3, 4 or 5, and pharmaceutically acceptable salts thereof. |
