Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

摘要

The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II):;
where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.

主权项

1. A compound of formulae I(A-E) having the following structure: wherein: the carbon atom designated * is in the R or S configuration; and X is phenyl, optionally substituted from 1 to 4 times with substituents as defined below in R14; R1 is H or C1-C6 alkyl; R2 is H; R3 is H; R4 is pyridazinyl, optionally substituted from 1 to 4 times with substituents as defined below in R14; R5 is H; R6 is H; R7 is H; R8 is H; R9 is H; and R14 is independently selected at each occurrence from a substituent in the group consisting of halogen and C1-C6 alkyl, wherein C1-C6 alkyl is optionally substituted from 1 to 3 times with halogen, or an oxide thereof, or a pharmaceutically acceptable salt thereof.