Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene

摘要

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an Antiviral gene, in particular, by targeting natural antisense polynucleotides of an Antiviral gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Antiviral genes.

主权项

1. A method of upregulating a function of and/or the expression of an Antiviral gene polynucleotide having SEQ ID NO: 3 in patient cells or tissues in vivo or in vitro comprising:
contacting said cells or tissues with at least one antisense oligonucleotide 12 to 30 nucleotides in length wherein said at least one oligonucleotide is specific for a natural antisense polynucleotide of the antiviral acne and has at least 90% sequence identity to a 12 to 30 nucleotide ration of a reverse complement of the natural antisense polynucleotide of the Antiviral gene polynucleotide; thereby upregulating a function of and/or the expression of the Antiviral gene polynucleotide in patient cells or tissues in vivo or in vitro.