Method for estimating haeomodynamic parameters by joint estimation of the parameters of a global perfusion model

摘要

The invention relates to a method for estimating haemodynamic perfusion parameters of an elementary volume—termed a voxel—of an organ, from perfusion signals by jointly estimating the parameters of an optionally limited comprehensive perfusion model. The invention moreover relates to a processing unit of a perfusion imaging analysis system, adapted for carrying out such a method and for delivering the estimated parameters according to an appropriate format to a human-machine interface able to represent said estimated parameters for a user.

主权项

1. A method for estimating and presenting a representation of one or more haemodynamic perfusion parameters of an elementary volume, referred to as a voxel, of an organ, said method being implemented by a processing unit of a perfusion imaging analysis system, and comprising:
obtaining perfusion signals S(t) derived from images of the organ; estimating the haemodynamic parameter or parameters using a joint estimation of the parameters Θ of a global perfusion model comprising:
a first relationship between the perfusion signal S(t) and a concentration C(t) of a contrast agent circulating in said voxel over a time t,a second relationship between the concentration C(t) of a contrast agent, the blood flow BF, a parametric or semiparametric model Ca(t,Θa) of an arterial input function and a parametric or semiparametric model R(t,ΘR) of a complementary cumulative distribution function of the transit time in the voxel, Θa and ΘR being respectively the parameters of the models Ca(t,Θa) and R(t,ΘR), anda third relationship Ψ(Θa)=0 between the parameters Θa of the model of the arterial input function Ca(tΘa); and displaying a graphical representation of the estimated value or values for the parameter or parameters on a human-machine interface for evaluation by a user.