主权项 |
1. A compound of formula (I):or a pharmaceutically acceptable salt thereof, wherein
R1 is selected from H, NRaRa, C1-6alkyl substituted with 0-5 R1a, C2-6alkenyl substituted with 0-5 R1a, C2-6alkynyl substituted with 0-5 R1a, —(CHR)r-carbocyclyl substituted with 0-5 R1a, —(CHR)r— heterocyclyl substituted with 0-5 R1a; R1a, at each occurrence, is independently selected from C1-6alkyl substituted with 0-5 Re, C2-6alkenyl substituted with 0-5 Re, C2-6alkynyl substituted with 0-5 Re, C1-6haloalkyl, F, Cl, Br, NO2, CN, ═O, —(CHR)rOH, —(CHR)rSH, (CHR)rORb, —(CHR)rS(O)pRb, —(CHR)rC(O)Rd, —(CHR)rNRaRa, —(CHR)rC(O)NRaRa, —(CHR)rC(O)NRaNRaRa, —(CHR)rNRaC(O)Rd, —(CHR)rNRaC(O)ORb, —(CHR)rNRaC(O)(CRR)rOC(O)NRaRa, —(CHR)rNRaC(O)(CRR)rNRaRa, —(CHR)rNRaC(O)(CRR)rNRaC(O)ORd, —(CHR)rOC(O)NRaRa, —(CHR)rC(O)ORd, —(CHR)rS(O)pNRaRa, —(CHR)rNRaS(O)pRb, —(CHR)r-carbocyclyl substituted with 0-5 Re and —(CHR)r-heterocyclyl substituted with 0-5 Re; R2 is selected from H and C1-6alkyl substituted with 0-3 R2a; R2a is selected from F, Cl, and Br; alternatively, R1 and R2 are taken together with the nitrogen atom to which they are attached to form a heterocyclyl substituted with 0-5 R1a; R3 is selected from aryl substituted with 0-5 R3a and heteroaryl substituted with 0-5 R3a; R3a, at each occurrence, is independently selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, F, Cl, Br, NO2, CN, —OH, —SH, —ORb, —S(O)pRb, C(O)Rd, —NRaRa, —C(O)NRaRa, —NRaC(O)Rd, —NRaC(O)ORb, —OC(O)NRaRa, —C(O)ORd, —S(O)pNRaRa, —NRaS(O)pRb; R4 is selected from H, C1-6alkyl, and C3-6cycloalkyl; Ra, at each occurrence, is independently selected from H, NH2, C1-6alkyl substituted with 0-3 Re, C2-6alkenyl substituted with 0-3 Re, C2-6alkynyl substituted with 0-3 Re, C1-6haloalkyl, —(CH2)rOH, (CH2)rcarbocyclyl substituted with 0-3 Re, and (CH2)r-heterocyclyl substituted with 0-3 Re, or Ra and Ra together with the nitrogen atom to which they are attached form a heterocyclyl substituted with 0-3 Re; Rb, at each occurrence, is independently selected from C1-6alkyl substituted with 0-3 Re, C1-6haloalkyl, C2-6alkenyl substituted with 0-3 Re, C2-6alkynyl substituted with 0-3 Re, —(CH2)rcarbocyclyl substituted with 0-3 Re, and —(CH2)rheterocyclyl substituted with 0-3 Re; Rd, at each occurrence, is independently selected from H, C1-6alkyl substituted with 0-3 Re, C1-6haloalkyl, C2-6alkenyl substituted with 0-3 Re, C2-6alkynyl substituted with 0-3 Re, —(CH2)r— carbocyclyl substituted with 0-3 Re, and —(CH2)r-heterocyclyl substituted with 0-3 Re; Re, at each occurrence, is independently selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, (CH2)rC3-6cycloalkyl, F, Cl, Br, CN, NO2, CO2H, ═O, —C(O)NRfRf, (CF2)rCF3, —(CH2)rOC1-5alkyl, —(CH2)rOH, SH, —(CH2)rSC1-5alkyl, —(CH2)rNRfRf, —(CH2)rphenyl, and (CH2)rheterocyclyl; Rf, at each occurrence, is independently selected from H, C1-5alkyl, C3-6cycloalkyl, and phenyl; R, at each occurrence, is independently selected from H, —(CH2)rOH, C1-6alkyl, C1-6haloalkyl, and —(CH2)r-aryl; p, at each occurrence, is independently selected from 0, 1, and 2; and r, at each occurrence, is independently selected from 0, 1, 2, 3, and 4. |