发明名称 |
Preparation of low molecular weight polyornithine in high yield |
摘要 |
The present invention generally relates to the large-scale (e.g., greater than 1 kg scale) preparation of low molecular weight polylysine or polyornithine in high yield by preparing a polylysine or polyornithine having a weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons and hydrolyzing it to produce a polylysine or polyornithine having a weight average molecular weight from about 5,500 Daltons to about 12,000 Daltons. |
申请公布号 |
US8791226(B2) |
申请公布日期 |
2014.07.29 |
申请号 |
US201313759247 |
申请日期 |
2013.02.05 |
申请人 |
Sigma-Aldrich Co. LLC |
发明人 |
Ponnusamy Ettigounder |
分类号 |
C08G69/10 |
主分类号 |
C08G69/10 |
代理机构 |
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代理人 |
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主权项 |
1. A process for the preparation of a polyornithine polymer comprising repeating units corresponding to Formula 3 or a salt thereof and having an ornithine-basis weight average molecular weight from about 5,500 to about 12,000 Daltons, the process comprising:
hydrolyzing a deprotected polyornithine intermediate comprising repeating units corresponding to Formula 3 or a salt thereof and having an ornithine-basis weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons, wherein Formula 3 has the structure: n is 3; and said polyornithine polymer is a homopolymer of ornithine. |
地址 |
St. Louis MO US |