Compositions and methods for alleviating depression or improving cognition

摘要

This application describes compositions of receptor inhibitors, including antipsychotic agents, for example haloperidol, and methods of use for alleviating clinical depression, improving cognition and/or treating other syndromes, conditions or diseases for which anti-depressant agents are prescribed. Furthermore, this application describes compositions and methods to induce supersensitivity in dopamine D2 and other receptors involved in depression and/or cognition as a means of alleviating clinical depression or improving cognition.

主权项

1. A method of treating depression comprising administering, to a subject in need thereof, an amount of haloperidol that is effective to elevate amounts of the high affinity state of the dopamine D2 receptor, inducing receptor supersensitivity, wherein the haloperidol is administered orally at a dosage of 0.05 mg to 0.5 mg each day for 3, 4, 5, 6, 7, 8, 9 or 10 consecutive days.