发明名称 |
Eutectic-based self-nanoemulsified drug delivery system |
摘要 |
A eutectic-based self-nanoemulsified drug delivery system (SNEDDS) is formulated from polyoxyl 35 castor oil (Cremophor), medium chain mono- and diglycerides (capmul), essential oils, and a pharmacologically effective drug. The preferred pharmacologically effective drug is a poorly water soluble drug, such as ubiquinone (CoQ10). The SNEDDS can be further incorporated into a powder to produce a solid dosage form. The solid dosage form contains the SNEDDS, a copolymer of vinylpyrrolidone and vinyl acetate (Kollidon VA 64), maltodextrin, and microcrystalline cellulose (MCC). |
申请公布号 |
US8790723(B2) |
申请公布日期 |
2014.07.29 |
申请号 |
US201213433284 |
申请日期 |
2012.03.28 |
申请人 |
Jarrow Formulas, Inc. |
发明人 |
Khan Mansoor A;Nazzal Sami |
分类号 |
A61K36/752;A61K36/00 |
主分类号 |
A61K36/752 |
代理机构 |
McCarter & English LLP |
代理人 |
McCarter & English LLP |
主权项 |
1. An orally administered dietary supplement comprising coenzyme Q10 (CoQ10), and a sufficient amount of a volatile essential oil to form a solution or oily melt at or below body temperature, and thereby solubilize the CoQ10 comprised in the orally administered dietary supplement at or below body temperature, and one or more additional ingredient wherein the amount by weight of the essential oil relative to the total weight is sufficient to maintain CoQ10 in solution at or below body temperature. |
地址 |
Los Angeles CA US |