| 发明名称 | Compositions and methods for treatment and prevention of osteoarthritis | ||
| 摘要 | The present invention is in the fields of medicine, pharmaceuticals, neutraceuticals and rheumatology. In one aspect, the invention provides pharmaceutical compositions for the treatment and/or prevention of osteoarthritis in mammals, particularly humans, comprising sodium bicarbonate and calcium gluconate, and optionally comprising one or more additional components. The invention also provides methods of treating or preventing osteoarthritis by administering to a mammal, preferably via intraarticular injection, one or more compositions of the invention. | ||
| 申请公布号 | US8790714(B2) | 申请公布日期 | 2014.07.29 |
| 申请号 | US200812185603 | 申请日期 | 2008.08.04 |
| 申请人 | Nucitec, S.A. de C.V. | 发明人 | Amador Ricardo;Rosado Jorge L.;García-Padilla Sandra;Duarte-Vázquez Miguel Ángel |
| 分类号 | A61K33/00;A61K31/191 | 主分类号 | A61K33/00 |
| 代理机构 | Sterne, Kessler, Goldstein & Fox P.L.L.C. | 代理人 | Sterne, Kessler, Goldstein & Fox P.L.L.C. |
| 主权项 | 1. A pharmaceutical composition for the treatment of osteoarthritis in a mammal, comprising: sodium bicarbonate at a concentration of from about 5-10% (w/v); calcium gluconate, at a concentration of from about 0.5%-5% (w/v); buffer in an amount effective to provide a pH range of about 4.5 to about 7.4 for the composition; isotonicity agent in an amount effective to provide an osmolality of about 220 mosmol/kg to about 350 mosmol/kg for the composition; QS water as a solvent; wherein the composition is an aqueous solution that is aseptically-manufactured and sterile. | ||
| 地址 | Queretaro MX | ||