Modified hyaluronic acid polymer compositions and related methods

摘要

The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.

主权项

1. A hydrogel formed by reaction of a hyaluronic acid having from 1-10% of its hydroxyl groups derivatized by reaction with divinyl sulfone with a thiol crosslinker having from two to eight thiol groups.