| 主权项 |
1. A compound of formula I in which R1 denotes which is optionally mono- or disubstituted by A, Hal, NR2, (CR2)nCN and/or OR5, D denotes C or S, G denotes N, R2 is absent, Q denotes unbranched or branched alkylene having 1, 2, 3 or 4 C atoms, in which 1-5 H atoms may be replaced by A, (CR2)n[X(CR2)n]p—Y, F and/or Cl, R3 denotes H, A, Ar, OR, SR, NR2, Hal, NO2, CN or (CR2)n[X(CR2)n]p—Y, X denotes O, NR or CR2, Y denotes OR or NR2, R5 denotes H or unbranched or branched alkyl having 1, 2, 3, 4, 5 or 6 C atoms, in which 1-7 H atoms may be replaced by F and/or Cl, E denotes COO(CR2)n, COO(CRR4), CO(CR2)mO, CONH(CR2)n, C(═S)NH(CR2)n, S(O)qNH(CR2)n, S(O)q(CR2)n, COCH2CH2, CO(CR2)mO(CR2)n, CO(CR2)mNH(CR2)n, CO(CH2)nCO, COCHR6CHR7, C(═S)O(CR2)n, CO(CRR4)(CR2)n, COO(CRR4), (CRR4)(CR2)n, S(O)qCR═CR, COCR═CR, CONH(CR2)mCRR4 or (CR2)mCONR, R4 denotes COOR5, Ar1, NRCOOR8, (CR2)nNR2 or NRCOOA, R6,R7 together denote (CH2)1-4, R8 denotes phenyl, naphthyl or fluorenyl, R denotes H or unbranched or branched alkyl having 1, 2, 3, 4, 5 or 6 C atoms, W denotes Ar or Het, Ar denotes phenyl, indanyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, (CR2)nOR, O(CR2)n, Ar1, (CR2)nNR2, SR, NO2, CN, COOR, CONR2, NRCOA, NRSO2A, SO2NR2, S(O)qA, CO-Het, (CR2)nHet, O(CR2)nNR2, O(CR2)nHet, NHCOOA, NHCONR2, NHCOO(CR2)nNR2, NHCOO(CR2)nHet, CR5═CR5Ar1, SO2Het, NHCONH(CR2)nNR2, NHCONH(CR2)nHet, OCONH(CR2)nNR2, OCONH(CR2)nHet, CONR(CR2)nNR2, CONR(CR2)nHet and/or COA, Het denotes a mono-, bi- or tricyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono-, di- or trisubstituted by Hal, A, (CR2)nAr1, O(CR2)nAr1, (CR2)nOR, (CR2)nNR2, SR, NO2, CN, COOR, CONR2, NRCOA, NRSO2A, SO2NR2, S(O)qA, CO-Het1, (CR2)nHet1, O(CR2)nNR2, O(CR2)nHet1, NHCOOA, NHCONR2, NHCOO(CR2)nNR2, NHCOO(CR2)n-Het1, NHCONH(CR2)nNR2, NHCONH(CR2)nHet1, OCONH(CR2)nNR2, OCONH(CR2)nHet1, CO-Het1, CHO, COA, ═S, ═NH, ═NA and/or ═O (carbonyl oxygen), Het1 denotes a monocyclic saturated heterocycle having 1 to 2 N and/or O atoms, which may be mono- or disubstituted by A, OA, OH, Hal and/or ═O (carbonyl oxygen), Ar1 denotes phenyl which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, CN, A and/or (CR2)nOR, A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms may be replaced by OR, CN, NR2, F and/or Cl and/or in which one or two non-adjacent CH2 groups may be replaced by O, NH, S, SO, SO2 and/or by CH═CH groups,
orcyclic alkyl having 3-7 C atoms, m denotes 1, 2, 3, 4, 5 or 6, n denotes 0, 1, 2, 3, 4, 5, 6, 7 or 8, p denotes 1, 2, 3, 4, 5 or 6, q denotes 0, 1 or 2, and Hal denotes F, Cl, Br or I, or a pharmaceutically acceptable tautomer, salt or stereoisomer thereof. |
