Modulating neuromuscular junction density changes in botulinum-toxin treated tissue

摘要

A method may include administering botulinum toxin to a tissue of a patient and administering a neuropeptide of the CRF family to the tissue of the patient. In some examples, the botulinum toxin is periodically administered to the tissue of the patient and/or the neuropeptide of the CRF family is periodically administered to the tissue of the patient. The periods with which the botulinum toxin and the neuropeptide of the CRF family are administered may be the same or may be different. In some examples, the botulinum toxin and the neuropeptide of the CRF family are administered to the tissue at substantially the same time, while in other embodiments, the botulinum toxin and the neuropeptide of the CRF family are administered to the tissue at different times.

主权项

1. A method comprising:
administering an amount of botulinum toxin to a facial muscle tissue of a patient so as to cause paresis or paralysis of said muscle tissue; and administering an amount of a neuropeptide of the corticotropin releasing factor (CRF) family to said muscle tissue of the patient effective to increase the duration of said paresis or paralyis.