| 摘要 |
Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease. |
| 主权项 |
1. A method of therapeutically treating a human patient having AL amyloidosis characterized by the presence of amyloid light chain-type (AL) protein fibrils comprising administering to the patient an effective dosage of an antibody or fragment thereof that specifically binds to an epitope comprising X1EDX2 in an aggregated AL protein, wherein X1 is H, T, S, P, A, L, C, Q, R, or E, and wherein X2 is T, S, E, R, I, F, A, G, M, L, N, or P, to thereby treat AL amyloidosis. |
