Pharmaceutical composition of nanoparticles

摘要

The invention discloses use of a pharmaceutical composition for slow-release delivery of a bioactive agent, comprising mixing the bioactive agent with a partially hydrophobic chitosan solution at a low pH and delivering the hydrogel at a physiological pH to transform the hydrogel to a solid complex for releasing the bioactive agent. The partially hydrophobic chitosan is characterized by presence of alternating charges of protonated amine groups and hydrophobic side groups.

主权项

1. A method for slow-release of a bioactive agent to an animal subject, said method comprising (1) mixing said bioactive agent with a chitosan-containing solution at a low pH that effects dispersion of said bioactive agent in the chitosan-containing solution, thus forming a liquid mixture of chitosan that is present in said chitosan-containing solution and said bioactive agent, wherein said chitosan is characterized by presence of alternating charges of protonated amine groups and hydrophobic side groups; (2) raising a pH of the liquid mixture to effectively transition said mixture to a phase of malleable hydrogel; and (3) delivering said malleable hydrogel to said animal subject, wherein a body pH transforms the malleable hydrogel to a solid complex, said complex thus releasing said bioactive agent in a slow-release mode to said animal subject.